Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/259690067?client_source=feed&format=rss
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The Android-powered Ouya?game console is still on schedule according to the developers' latest update, and they've confirmed that it will launch with Jelly Bean. It wouldn't be surprising to see Android 4.2 folded in before the planned launch early next year, even though that version was just unveiled a few days ago. Apparently the Ouya?folks?have been busy talking with developers over the last few months, which is key considering porting high-resolution games to the big screen and optimizing controls for Ouya's hardware will be key to its initial success.?
To that end, they've outlined a few tips for developers in advance of the December launch of the Ouya SDK. For example, the gamepad will have a single-finger touchpad and a button for system-wide access to shutting down or quitting a game, but none of the familiar buttons like back or menu. Apps should be ready to run at 720p, 1080p, and 1080i resolutions. Notifications aren't employed, and all games are effectively free (though laden with ads and in-app purchases as the game creators see fit). Finally, Ouya reminds app-makers that the system is built for Tegra, and that anyone itching to get their game optimized should test with an Nvidia-powered?Android tablet.?
As for the hardware, they've got the circuit boards printed, and are busy optimizing software and preparing dev kits for those that got in early.?
So, who backed Ouya? Any developers getting ready to make their games ready for the promising young system?
Source: Ouya
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Source: http://www.androidcentral.com/ouya-confirms-game-console-will-launch-jelly-bean
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Oct 19, 2012
Most people assume that because they have the perfect pair of Adidas trainers, K-Swiss trainers, Nike trainers or even the Timberland boots that they will always find it easy to buy these online. Well, the fact is that online stores are constantly changing as well the manufacturers of these Nike trainers or K-Swiss trainers.
Hence, it is always best to heed the advice of experts in terms of buying the K-Swiss trainers or Adidas trainers that best fit the feet. In fact, professional shoe runners compare the shoe buying to purchasing Men's Polo Shirts. There are always different trends and styles that are increasing in demand and it would be best to figure out the best tips on how to get the best pair of Nike trainers or K-Swiss trainers.
The Basic Shopping Tips to Keep in Mind
The online shopping is already considered to be quite a convenient and easy thing to do. However, the fact is that the Nike trainers, Adidas trainers or the Timberland boots that are offered online are quite harder to pick because you physically cannot fit or see these pairs of shoes. It is already proven that you want to get the Timberland boots or the Adidas trainers that will be comfortable and easy on the feet. Nevertheless, the fact is that online shopping is essentially a different arena. In fact, even shopping online for the Men's Polo Shirts is entirely different experience.
The most essential thing to consider when buying the Adidas trainers or the K-Swiss trainers online is the retailers offering these items for sale. More and more people are opting to buy the Adidas trainers, K-Swiss trainers, Timberland boots, and even the Men's Polo Shirts online. Primarily, the main benefit or reason they consider this choice is they get the convenience of buying anytime they want. With accessibility to such renowned brands such as the Nike trainers, Adidas trainers, and the Timberland boots, it would be wise to be quite selective in terms of the seller.
Another thing that often needs consideration in buying the Nike trainers, Adidas trainers or the Timberland boots is the shipping charges. As these K-Swiss trainers and more are delivered straight to the doorstep of your homes, it is expected there will be fees to pay. There are actually some stores that try to give this delivery charge for free provided a certain minimum limit of purchase for the Nike trainers, Adidas trainers and even the Men's Polo Shirts are met or exceeded. The truth is that it is always important for you to consider the shipping charges of the store prior to getting these products to your shopping cart.
Return and exchange policies must be considered and read prior to the actual shopping of the different products. It is quite a feat if you are able to get the Nike trainers or the K-Swiss trainers from a store that really offers quite a great policy. Typically, this is actually considered as an important aspect as the Nike trainers and the Adidas trainers have not been tried and tested, and there might be issues that you may want to replace or addressed. While some stores will have great policies for the Adidas trainers and the K-Swiss trainers, there may be some things that need to be assessed such as the physical conditions of the shoes and such.
Online shopping is considered to be one of the best things that have been produced by the Internet. However, the risks for such are also inherent. One of the best trusted stores for the Timberland boots, Nike trainers, Adidas trainers, and even some Men's Polo Shirts can be found at www.sportsmart.co.uk.
About the Author
I am Heather Joe, expert writer on Sportsmart services.
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Source: http://www.artipot.com/articles/1408851/discover-the-best-adidas-or-k-swiss-trainers-online.htm
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Meet Ellie (#6457). She?s a gorgeous 4 yr old Palomino mare from the Calico Mts. She is at the Palomino Valley Center near Reno. (Photo courtesy BLM)
Taking action to find homes for at-risk wild horses
Protect Mustangs is working with members of the public to find homes for all the wild horses who were not adopted during the recent Bureau of Land Management (BLM) internet adoption. The unadopted are at risk of being sold to pro-slaughter people like Tom Davis.
?We are reaching out to the public through Facebook and Twitter to find adopters,? explains Anne Novak, executive director of Protect Mustangs. ?People across the country are expressing interest in adopting these great horses. I don?t know why the BLM isn?t marketing the adoption program better.?
BLM?s three strike program
America?s living legends receive a strike against them every time they are offered for adoption. Just living at a short term holding facility with a tag around their neck counts as a strike if they are not adopted. Then if they are offered on the internet and not adopted they get another strike. If they are offered for adoption at an event and don?t find their person then they get their third strike . . . It?s a cruel system. After three strikes the federally protected wild horses can be sold to anyone who signs on the dotted line that they won?t sell them to slaughter or for use as rodeo stock. The BLM doesn?t check that the buyers are complying so it?s a free for all.
?If indigenous wild horses are not adopted then they will be shipped out to the Midwest where they are at-risk of being sold by the truckloads?even the one year olds,? states Novak. ?With the recent E.U. crackdown on American horse meat, riddled with toxic substances, we are concerned wild horses face an increased risk of going to slaughter because they have never been given substances such as bute.?
Members of the public may email Contact@ProtectMustangs.org to enlist their help in communicating with BLM for a smooth adoption process as well as getting information on trainers and transportation.
Below are some wild horses available for adoption:

Meet Baby Red (#2484) a sorrel yearling gelding. His mother was captured during the Twin Peaks roundup and he was born at the BLM facility in California near Susanville. (Photo courtesy BLM)
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Lily (#3361) is from the Fox Hog herd. They have some draft in their line and make wonderful pets/riding horses when you give them a lot of love. (Photo courtesy BLM)

Sam (#3275) is from California?s High Rock area and appears to be from cavalry stock. He is handsome and might make a nice little jumper or sport horse.
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Meet Stuart (#2600), a yearling gelding from High Rock in California (eastern Sierra). This internet auction could be his 3rd strike and put him ?at risk?. He is located near Susanville, California. (Photo courtesy BLM)
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Here is Merlot (#9380) a yearling red roan gelding from Green Mountain, Wyoming. He is located in Rock Springs, WY and can be shipped to various locations.
To learn about these horses and others in need of adoption, visit Protect Mustangs on Facebook: https://www.facebook.com/ProtectMustangs
This is from the BLM website:
Applicant must be 18 years of age or older.
Applicant must have access to a stall/corral that meets the following criteria:
Applicant must describe their stall/corral, etc. in the application packet and submit to BLM for approval.
Source: http://protectmustangs.org/?p=2787
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NEW YORK (AP) ? Robert Caro, Junot Diaz and the late Anthony Shadid were among the finalists announced Wednesday for the National Book Awards.
Other nominees included the novelists Dave Eggers and Louise Erdrich and nonfiction writers Anne Applebaum and Katherine Boo. Twenty authors, five each in four competitive categories, were picked. The winners will be announced Nov. 14 at a ceremony hosted by the commentator and performer Faith Salie.
Major New York publishers have complained in recent years that such high profile books as Jonathan Franzen's "Freedom" and Jeffrey Eugenides' "The Marriage Plot" have been overlooked in favor of more obscure titles. But this year's picks include some of the most talked about literary works of 2012, from Caro's "The Passage of Power," the fourth of his epic Lyndon Johnson series; to Diaz's "This is How You Lose Her," a series of stories about love; to Katherine Boo's "Behind the Beautiful Forevers: Life, Death, and Hope in a Mumbai Undercity," widely praised as a masterpiece of nonfiction narrative.
The nominees include five Pulitzer Prize winners (Caro, Shadid and Anne Applebaum among them), a National Book Award winner (Caro) and two MacArthur "genius" grant recipients, most recently Diaz. Judges also picked five debut books, including Kevin Powers' "The Yellow Birds," which some critics have cited as a rare major novel about the Iraq war; and Domingo Martinez's "The Boy Kings of Texas," a memoir. Panels of fellow writers that change each year choose the awards.
The NBAs are administered by the nonprofit National Book Foundation, which has long sought to strike a balance between making the awards a mark of literary excellence and of popular appeal. Past hosts of the ceremony have included Steve Martin and Garrison Keillor and this year's picks were revealed Wednesday on MSNBC's "Morning Joe."
Book foundation executive director Harold Augenbraum said that no changes were made in the selection process, but that extra steps were added to prevent a fiasco like in 2011, when a miscommunication between judges and the foundation led to Lauren Myracle's being mistakenly announced as a young people's literature finalist. Her nomination was then withdrawn, a humiliation for the author and an embarrassment for the awards.
"When the panel chair called in we asked for author, title, and publisher," Augenbraum said of this year's process. "Then we pulled our copies of the books, checked the information, and then later a different staff person called the panel chair back to verify all the information."
The fiction finalists were Diaz, Powers, Eggers ("A Hologram for the King"), Erdrich ("The Round House") and Ben Fountain, for "Billy Lynn's Long Halftime Walk." Besides Caro, Martinez and Boo, nonfiction nominees were Applebaum for "Iron Curtain" and Shadid for the memoir "House of Stone." Shadid, a New York Times foreign correspondent who previously worked for the Washington Post and The Associated Press, died of an asthma attack in February at age 43.
In poetry, the finalists were David Ferry's "Bewilderment: New Poems and Translations," Cynthia Huntington's "Heavenly Bodies," Tim Seibles's "Fast Animal," Alan Shapiro's "Night of the Republic" and Susan Wheeler's "Meme."
The young people's literature finalists: William Alexander's "Goblin Secrets," Carrie Arcos's "Out of Reach," Patricia McCormick's "Never Fall Down," Eliot Schrefer's "Endangered" and Steve Sheinkin's "Bomb: The Race to Build ? and Steal ? the World's Most Dangerous Weapon."
Judges looked through nearly 1,300 books, including 479 nonfiction works and 311 for fiction.
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On this occasion we would like to focus the theme of Technology Business Continuity and not just Disaster Recovery, because when we talk about Business Continuity Technology is important to note that we refer to the fact of having the planning, tools and strategies that allow for a smooth operation of the business technology platform at any time and in any situation that is present even when there is a disaster. Having strategies Technology Business Continuity planning and efficient, gives companies the opportunity to operate under a continuous scheme of work, solve the variety of problems that present themselves in business activities and allow all the elements necessary to operate, continue to function properly. Very different situation when we talk or talk about Disaster Recovery, as this will only be carried out when for some reason internal or external, the technological platform operations have been discontinued and is necessary to resort to actions or strategies Disaster Recovery aimed keep or retrieve information, and keep running despite the disaster that has been submitted.
It is quite natural that companies or businesses that suffer the consequences of a disaster or those who want to prevent having to interrupt its services or operations, consider the implementation of a Disaster Recovery strategy is sufficient, when in fact what it is essential to conduct proper Continuity Planning Technology. For Carlos Kornhauser, independent consultant and contributor to Pink Elephant: ?Today, many companies are concerned about how to recover from a disaster, not understanding that it is not only a disaster recovery from the technological point of view, but how to be prepared to ensure continuity of business operation in any contingency, not just the best way to respond to a disaster. ?
Considering this, we can understand that the Disaster Recovery strategies are only part of the strategy of continuity, but for the full picture we must take into account all elements of functioning, such as: the processes, people and This physical locations. You need to know and differentiate the different factors that can support the business to define both continuity strategies and recovery strategies, for example, knowing how long our information may persist after an incident, how much information could be lost or found in planned backups based on the operation of the business.
Carlos Kornhauser believes that ?The more aligned are the areas of business and IT to understand what the impacts that an organization or business may be based on operational discontinuity of the technology platform, can make decisions on how to invest in items that will maintain the continuity of the operation that is requiring the business ? It is essential for the optimal operation of the business and the strategies implemented to validate the correct continuity of operations, provide proper monitoring and assessing the various aspects that influence the success of strategies. Any Continuity Plan and Disaster Recovery Strategy should be tested periodically to ensure operation and keep it updated to respond to the natural movement of the business.
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A wounded Pakistani girl, Malala Yousufzai, is moved to a helicopter to be taken to Peshawar for treatment in Mingora, Swat Valley, Pakistan on Tuesday, Oct. 9, 2012. A Taliban gunman walked up to a bus taking children home from school in Pakistan?s volatile Swat Valley Tuesday and shot and wounded a 14-year-old activist known for championing the education of girls and publicizing atrocities committed by the Taliban, officials said. (AP Photo/Sherin Zada)
A wounded Pakistani girl, Malala Yousufzai, is moved to a helicopter to be taken to Peshawar for treatment in Mingora, Swat Valley, Pakistan on Tuesday, Oct. 9, 2012. A Taliban gunman walked up to a bus taking children home from school in Pakistan?s volatile Swat Valley Tuesday and shot and wounded a 14-year-old activist known for championing the education of girls and publicizing atrocities committed by the Taliban, officials said. (AP Photo/Sherin Zada)
In this photo released by Inter Services Public Relations department, Pakistani soldiers carry wounded Pakistani girl, Malala Yousufzai, from a military helicopter to a military hospital in Peshawar, Pakistan. A Taliban gunman walked up to a bus taking children home from school in Pakistan?s volatile Swat Valley Tuesday and shot and wounded the 14-year-old activist known for championing the education of girls and publicizing atrocities committed by the Taliban, officials said. (AP Photo/Inter Services Public Relations Department)
A wounded Pakistani girl, Malala Yousufzai, is moved to a helicopter to be taken to Peshawar for treatment in Mingora, Swat Valley, Pakistan, Tuesday, Oct. 9, 2012. A Taliban gunman walked up to a bus taking children home from school in Pakistan?s volatile Swat Valley Tuesday and shot and wounded a 14-year-old activist known for championing the education of girls and publicizing atrocities committed by the Taliban, officials said.(AP Photo/Sherin Zada)
MINGORA, Pakistan (AP) ? Fourteen-year-old Malala Yousufzai was admired across a battle-scarred region of Pakistan for exposing the Taliban's atrocities and advocating for girls' education in the face of religious extremists. On Tuesday, the Taliban nearly killed her to quiet her message.
A gunman walked up to a bus taking children home from school in the volatile northern Swat Valley and shot Malala in the head and neck. Another girl on the bus was also wounded.
The young activist was airlifted by helicopter to a military hospital in the frontier city of Peshawar. A doctor in the city of Mingora, Tariq Mohammad, said her wounds weren't life-threatening, but a provincial information minister said after a medical board examined the girl that the next few days would be crucial.
Malala began writing a blog when she was just 11 under the pseudonym Gul Makai for the BBC about life under the Taliban, and began speaking out publicly in 2009 about the need for girls' education ? which the Taliban strongly opposes. The extremist movement was quick to claim responsibility for shooting her.
"This was a new chapter of obscenity, and we have to finish this chapter," Taliban spokesman Ahsanullah Ahsan by telephone.
The shooting provoked outrage across the country, angering Pakistanis who have seen a succession of stories about violence against women by the Taliban.
"This attack cannot scare us nor the courageous Malala. This cowardly act cannot deter Malala to give up her efforts," said Azizul Hasan, one of the girl's cousins.
Prime Minister Raja Pervaiz Ashraf condemned the attack and called her a daughter of Pakistan. State Department spokeswoman Victoria Nuland called the shooting "barbaric" and "cowardly."
Leila Zerrougui, the U.N. special representative for children in armed conflict, condemned the attack "in the harshest terms." ''Education is a fundamental right for all children," she said in a statement. The Taliban "must respect the right to education of all children, including girls, to go to school and live in peace."
The attack displayed the viciousness of Islamic militants in the Swat Valley, where the military conducted a major operation in 2009 to clear out insurgents, and a reminder of the challenges the government faces in keeping the area free of militant influence.
In her BBC blog, Malala wrote about not wearing her uniform to school after officials warned it might attract the Taliban's attention, and how many other students moved out of the valley after the Taliban issued an edict banning girls from school. She wrote about the Taliban movement had kept her family from going out after sunset.
While chairing a children's assembly supported by UNICEF in the valley last year, the then-13-year-old championed a greater role for young people.
"Girl members play an active role," she said, according to an article on the U.N. organization's website. "We have highlighted important issues concerning children, especially promoting girls' education in Swat."
She was nominated last year for the International Children's Peace Prize, which is organized by the Dutch organization KidsRights to highlight the work of children around the world.
Malala was shot on her way home from a school run by her father, Ziauddin, who is also known in the valley for promoting education of girls.
The bus was about to leave the school grounds in Mingora, the largest city in Swat Valley, when a bearded man approached it and asked which one of the girls was Malala, said Rasool Shah, Mingora's police chief. Another girl pointed to Malala, but the activist denied it was her and the gunmen then shot both of the girls, the police chief said.
The Swat Valley ? nicknamed the Switzerland of Pakistan ? was once a popular tourist destination for Pakistanis. Honeymooners used to vacation in the numerous hotels dotted along the river of the same name running through it. But the Taliban's near-total takeover of the valley just 175 miles (280 kilometers) from the capital in 2008 shocked many Pakistanis, who considered militancy to be a far-away problem in Afghanistan or Pakistan's rugged tribal regions.
Militants began asserting their influence in the valley in 2007 ? part of a wave of al-Qaida and Taliban fighters expanding their reach from safe havens near the Afghan border.
By 2008 they controlled much of it and began meting out rules and their own brand of justice. During about two years of its rule, the Taliban forced men to grow beards, restricted women from going to the bazaar, whipped women they considered immoral and beheaded opponents.
Taliban militants in the region also destroyed around 200 schools. Most were girls' institutions, though some prominent boys' schools were struck as well. The private school owned and operated by Malala's father was temporarily closed under the Taliban.
At one point, the Taliban said they were halting female education, a move that echoed their militant brethren in neighboring Afghanistan who during their rule barred girls from attending school.
While the Pakistani military managed to flush out the insurgents during the military operation, the Taliban's top leadership escaped, leaving many of the valley's residents on edge.
Kamila Hayat, a senior official of the Human Rights Commission of Pakistan, said Malala's activism sent a global message that Pakistani girls could fight for their rights. But she also worried that Tuesday's shooting would prevent other parents from letting their children speak out against the Taliban.
"This is an attack to silence courage through a bullet," Hayat said. "These are the forces who want to take us to the dark ages."
The problems of young women in Pakistan were the focus of a separate case before the high court, which ordered a probe Tuesday into an alleged barter of seven girls to settle a blood feud in a remote southwestern district. The tradition of families exchanging unmarried girls to settle feuds is banned under Pakistani law but still practiced in the country's more conservative, tribal areas.
A tribal council ordered the barter in early September in the Dera Bugti district of Baluchistan province, the district deputy commissioner, Saeed Faisal, told the court. He did not know the girls' ages but local media reported they were between 4 and 13 years old.
The Advocate General for the province could not confirm the incident.
Chief Justice Iftikhar Chaudhry ordered Faisal to ensure that all members of the tribal council ? and a local lawmaker ? who belongs to one of the groups believed involved ? appear in court on Wednesday.
___
Santana reported from Islamabad. Associated Press writer Abdul Sattar in Quetta and Zarar Khan and Asif Shahzad in Islamabad contributed to this report.
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By NBC News wire services
Updated at 11:05 a.m. ET: Stocks edged lower Tuesday even after the IMF issued the latest forecast of slower global growth, leaving investors little reason to buy equities before the start of the U.S. quarterly earnings season.
The International Monetary Fund cut its projected global output for 2012 to 3.3 percent from 3.5 percent and forecast 3.6 percent growth next year. The international lender warned that a lack of action by U.S. and European policymakers to fix their economic problems could extend the current slump.
The IMF warnings come on the heels of a lowered forecast for growth in the East Asia-Pacific region by the World Bank on concerns China's slowdown could last longer than expected.
Repeated warnings about the economy have left investors cautious before what could be a disappointing earnings season after a rally that has pushed the S&P 500 up nearly 16 percent so far in 2012, lifting it to its highest in nearly five years.
But the market has remained stuck in a range for the past few days as investors wait to see how if there are any earnings surprises and what companies expect in the fourth quarter.
"You really have the headwind of slowing economic growth. The IMF warning is just another piece of evidence of that against the backdrop of incredibly loose monetary policy just holding everything in place," said Rick Meckler, president of investment firm LibertyView Capital Management in New York.
"There isn't really the earnings strength to take the market out of this range," he added.
Analysts forecast third-quarter earnings of S&P 500 companies would fall 2.3 percent from the year-ago quarter, according to Thomson Reuters data, which would be the first drop in U.S. quarterly earnings in three years.
Earnings season gets under way when Dow component Alcoa Inc reports quarterly earnings. Analysts expect Alcoa's third-quarter results to show the aluminum company broke even, down from a profit of 15 cents per share a year earlier, according to Thomson Reuters data.
Among large multinationals that have warned about earnings, citing weakness in Europe and China, are FedEx Corp, Caterpillar Inc and Hewlett-Packard Co.
Investors were also eyeing a euro zone finance ministers' meeting and a visit by German Chancellor Angela Merkel to Greece for any signs of progress in dealing with the region's debt crisis.
On Monday, the euro zone finance ministers and the IMF held a "thorough and robust" debate on Greece but failed to make significant progress in deciding how best to get the country back on track with its bailout program.
According to data, 91 companies in the S&P 500 have issued negative outlooks versus 21 positive pre-announcements, for a ratio of 4.3, the weakest showing since the third quarter of 2001.
Reuters contributed to this report.
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Before you vowed, ?Till death do us part,? did you talk to your partner about how many kids you wanted? About sex and monogamy? Your values about money? How you manage conflict?
Or, did you instead focus on planning the ?perfect? wedding and honeymoon?
You?re not alone. Most couples are so mesmerized by being in love they believe that love will carry them through and it will all just work out. Sadly, one out of two of those couples are wrong.
Have you ever wondered, ?Did I marry the ?right? person??
It is a common thought, especially among the couples who believed marriage would just work out, and it?s a thought you need to understand.
Were you expecting your marriage to be like your parents? relationship, or like that ?perfect? couple everyone envies, or like the idealized version featured in pop culture, such as the Cleavers or the Bradys?
Recent studies report that marriage is on the decline; with success rates hovering around 50%, it?s really not a big surprise. And unrealistic expectations can hinder a marriage from the get-go.
So we?re here to help you beat the odds and have a loving relationship that lasts a lifetime ? the one you?ve always wanted and deserve.
On this call, you?ll learn:
The Three Truths That Will Ensure Your Marriage Lasts a Lifetime
When: Thursday, October 25, 2012 ~ 8:00 ? 9:00 PM EST
Cost: Free
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What others are saying:![]()
I like the heart centeredness and consciousness of your work. Reading your articles has given me hope again and I feel refreshed in my heart. You have articulated what I have felt lately about the need for support and authenticity in a partnership. ~ Christine, Facebook Fan
Bob and Lori, I really appreciate the time you both put into this group. Your news feeds are ones that I look forward to reading every time I log in. I look forward for what you have in store for us tomorrow. ~ Audrey Fallon, Facebook Fan
I don?t know how you and Bob are so good at what you do. One thing that stands out, you apparently are a genuine, authentic and real couple with real life issues that you work through together. That is so much more meaningful to me than other professionals who may not be practicing what they preach. ~ Geoffrey Greaves, TeleClass Participant
Register for this month?s TeleClass.
Source: http://store.relationshipswork.com/2012/10/free-teleclass/
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ScienceDaily (Oct. 8, 2012) ? McGill researchers have identified a small region in the genome that conclusively plays a role in the development of psychiatric disease and obesity. The key lies in the genomic deletion of brain-derived neurotrophic factor, or BDNF, a nervous system growth factor that plays a critical role in brain development.
To determine the role of BDNF in humans, Prof. Carl Ernst, from McGill's Department of Psychiatry, Faculty of Medicine, screened over 35,000 people referred for genetic screening at clinics and over 30,000 control subjects in Canada, the U.S., and Europe. Overall, five individuals were identified with BDNF deletions, all of whom were obese, had a mild-moderate intellectual impairment, and had a mood disorder. Children had anxiety disorders, aggressive disorders, or attention deficit-hyperactivity disorder (ADHD), while post-pubescent subjects had anxiety and major depressive disorders. Subjects gradually gained weight as they aged, suggesting that obesity is a long-term process when BDNF is deleted.
"Scientists have been trying to find a region of the genome which plays a role in human psychopathology, searching for answers anywhere in our DNA that may give us a clue to the genetic causes of these types of disorders," says Prof. Ernst, who is also a researcher at the Douglas Mental Health University Institute. "Our study conclusively links a single region of the genome to mood and anxiety."
The findings, published in the Archives of General Psychiatry, reveal for the first time the link between BDNF deletion, cognition, and weight gain in humans. BDNF has been suspected to have many functions in the brain based on animal studies, but no study had shown what happens when BDNF is missing from the human genome. This research provides a step toward better understanding human behaviour and mood by clearly identifying genes that may be involved in mental disorders.
"Mood and anxiety can be seen like a house of cards. In this case, the walls of the house represent the myriad of biological interactions that maintain the structure," says Ernst, "Studying these moving parts can be tricky, so teasing apart even a single event is important. Linking a deletion in BDNF conclusively to mood and anxiety really tells us that it is possible to dissect the biological pathways involved in determining how we feel and act.
We now have a molecular pathway we are confident is involved in psychopathology," adds Ernst, "Because thousands of genes are involved in mood, anxiety, or obesity, it allows us to root our studies on a solid foundation. All of the participants in our study had mild-moderate intellectual disability, but most people with these cognitive problems do not have psychiatric problems -- so what is it about deletion of BDNF that affects mood? My hope now is to test the hypothesis that boosting BDNF in people with anxiety or depression might improve brain health."
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/8orHSCaiF4k/121008161850.htm
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The rain gutter and down pipes are there to prevent this from taking place. They accumulate the rainwater once it has gotten to the end of its descent.? From there the slight pitch in the guttering will definitely motivate the rain water in to the down pipeline, ultimately holding it down into the drainpipe and safely away.
The consequence of having incorrectly pitched rain gutters can easily have a comparable effect, and in some cases it can be also much worse. Improperly pitched rain gutters that are pitched far from the wall with also a slight gap is the equivalent of having no rain gutter whatsoever and you will definitely encounter comparable complications.?
Nevertheless if you have actually poorly pitched rain gutters that induce all the rain water to collect in one location, this rain is then likely to run down one region of the wall surface. Instead of all the rainwater from one day or one week being topped the whole wall structure it is now being concentrated in just one spot. The power of the water could erode the brickwork and the concrete work inducing severe architectural damage and internal wet and rot.? Both of these occasions will cost you a bunch more to straight compared to having your drainpipe dealt with or also having your poorly pitched gutters totally ripped down and switched out.
Incorrectly pitched rain gutters can easily end up costing you a huge amount of money and it is essential that you frequently examine that every little thing is operating smoothly. You may quickly inform whether a gutter is pitched appropriately by enjoying when it rainstorms. However, you need to have it examined consistently when you have your roofing inspected to make certain that the water really isn?t operating back into the roof covering due to the fact that this will also result in severe damages and it is hard to inform unless you understand just what you are looking for.
Nichole HobanCategories:?Gutter Downspout, Gutter Downspouts, Gutter Guard, Gutter Installation, Gutter Installers, Gutter Leaf Guards, Gutter Repair, Gutter Replacement Tags:?gutter contractor ma, gutter estimate ma, gutter price ma, gutter repair boston ma
Source: http://gfsprague.com/gutter-guard/the-problems-with-gutters-that-have-an-improper-pitch/
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In Venezuela's oil-rich east, some say the administration's management of natural resources ? including oil spills and refinery accidents ? has pushed them toward the opposition.
By Steven Bodzin,?Correspondent / October 6, 2012
Venezuelan President Hugo Ch?vez, greets supporters under a heavy rain during his closing campaign rally on Avenida Bolivar, in Caracas, Venezuela, Thursday, Oct. 4. Ch?vez is running for re-election against opposition candidate Henrique Capriles in presidential elections on Oct. 7.
Pedro Portal/The Miami Herald/AP
EnlargePuerto La Cruz, Venezuela
Here in the oil-rich eastern region of Venezuela, propaganda for President Hugo Ch?vez dominates the landscape, from spotless billboards by the airport to dusty banners over trash-strewn lots. A hillside water tank carries the name of Ch?vez?s PSUV party.
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Though President Ch?vez has spent years focusing on the region?s strategic importance, cultivating support for his party and its policies of ?21st century socialism,? his campaign has hit resistance here. And it has become one of the places where opposition candidate Henrique Capriles Radonski?stands to pick up votes when the country goes to the polls on Sunday.
Over the course of his nearly 14 years as President, Ch?vez has made it clear he wants supporters of his socialist revolution to control access to the region?s quarter trillion barrels of oil reserves. But with a record of oil spills, a rising accident rate in refineries, and social problems like the continent's highest murder rates and weekly blackouts, Ch?vez?s time in office may be working against him, weighing on his public support here, and across much of the country.
"It's very tight, and both have very similar chances of winning," says I?aki Sagarzazu, a Venezuelan teaching at the University of Glasgow, Scotland. "It will come down to who mobilizes the most."
Mr. Sagarzazu says that Ch?vez support has moved from urban to rural areas over the years. That?s left the president with a base in the plains while urban areas have moved largely to the opposition, which this year is supporting Mr. Capriles, governor of a state that includes part of the capital, Caracas.
Here in this region, too, people have shifted their support away from the incumbent.
"He never does what he says," says Reina, a mother of 11 and full-time homemaker, who was shy about talking to the press. She says she has supported Ch?vez for years, but is still undecided as to whether she will give him her vote again in a race that?s too close to call, with pollsters and analysts divided on which candidate is the most likely winner.
Venezuela is experiencing 18 percent inflation and there is a sense that neighbors, such as Brazil, have emerged more successfully from poverty. Such concerns are countering Ch?vez's emotional connection with the people and his ability to attract support with populist programs such as free homes. In the oil region, environmental issues have also affected the president's standing. One case is Monagas state, where the president received 71 percent support in the 2006 election.
A pipeline burst in the state Feb. 4, spilling thousands of barrels of crude into the Guarapiche river. Local opposition press reported that for the first hours of the disaster, the state oil company failed to halt the flow, in part because some employees were away in the capital for a rally commemorating the 20th anniversary of Ch?vez leading a failed military coup.
The spill forced managers to halt water withdrawals from the river, leaving about 200,000 residents of the city of Maturin with limited running water for six weeks.
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With most programmes I use, a deletion removes the file to either the recycle bin or to oblivion. And some offer you the option to chose which deletion routing your prefer. In either case the file is gone, unless you specifically restore it from the recycle bin.
I have no problem with FTM not offering the oblivion option, but would hope the developers will eventually allow the user to set a default of recycle bin or not, rather than having to make the choice for each individual deletion.
Bottom line however is my concern is not process or even wasted space, but whether there are functional or performance implications to having deleted files still hanging around.
Source: http://boards.ancestry.co.uk/topics.software.famtreemaker/9017.1.1/mb.ashx
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